CD31 − but Not CD31 + Cardiac Side Population Cells Exhibit Functional Cardiomyogenic Differentiation
نویسندگان
چکیده
منابع مشابه
CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation.
Heart failure remains a leading cause of morbidity and mortality. The cellular mechanism underlying the development of cardiac dysfunction is a decrease in the number of viable cardiomyocytes. Recent observations have suggested that the adult heart may contain a progenitor cell population. Side population (SP) cells, characterized by a distinct Hoechst dye efflux pattern, have been shown to exi...
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Cardiac resident stem/progenitor cells (CSC/CPCs) are critical to the cellular and functional integrity of the heart because they maintain myocardial cell homeostasis. Several populations of CSC/CPCs have been identified based on expression of different stem cell-associated antigens. Sca-1(+) cells in the cardiac tissue may be the most common CSC/CPCs. However, they are a heterogeneous cell pop...
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Angiogenesis, the formation of new blood vessels from preexisting ones, is a complex process consisting of interrelationships of angiogenic, survival and differentiation factors and their receptors with cell adhesion and cell-matrix adhesion molecules (Beck and D’Amore, 1997; Folkman and D’Amore, 1996; Hanahan, 1997; Hanahan and Folkman, 1996; Risau, 1997; Sage, 1997; Stromblad and Cheresh, 199...
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Early in life, thymic export establishes the size and the diversity of the human naive T-cell pool. Yet, on puberty thymic activity drastically decreases. Because the overall size of the naive T-cell pool decreases only marginally during ageing, peripheral postthymic expansion of naive T cells has been postulated to account partly for the maintenance of T-cell immunity in adults. So far, the an...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2005
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000173297.53793.fa